Mayo Clinic Pharmacy Grand Rounds

Level Up: Updates on Direct Oral Anticoagulant Plasma Levels

Nikitha Yagnala, PharmD (Twitter: @NikithaYagnala) describes laboratory tests used to estimate DOAC plasma levels, reviews current literature exploring the association between DOAC plasma levels and clinical outcomes and outlines appropriate utilization and interpretation of DOAC plasma levels in clinical practice.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Is Shorter Better? Early Discontinuation of Empiric Antibiotics in Febrile Neutropenia

Divya A. Khandekar, PharmD, MS (Twitter: @pharmdiv) describes the etiology of febrile neutropenia in patients with hematological malignancies, summarizes guideline-based recommendations for antibiotic discontinuation in patients with febrile neutropenia and discusses primary literature supporting early antibiotic discontinuation in patients with febrile neutropenia.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Long Acting Lipoglycopeptides: Antibiotic Friend or Foe?

Andrew J. Jatis, PharmD (Twitter: @jatis_rx) reviews the pharmacology and drug characteristics of dalbavancin and oritavancin, describes current literature assessing the safety and efficacy of FDA approved and off-label indications for lipoglycopeptide use in clinical practice and discusses pharmacoeconomic implications of lipoglycopeptide use in clinical practice.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Strategies to Reduce Relapse after Hematopoietic Cell Transplantation

Kaylee A. Clark, PharmD describes the basic principles of maintenance therapies after allogeneic HSCT, discusses evidence and guideline recommendations for maintenance therapies after allogeneic HSCT for acute lymphoblastic leukemia and reviews evidence and guideline recommendations for maintenance therapies after allogeneic HSCT for acute myeloid leukemia.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Process Management Techniques to Improve Patient Safety

Kyle J. Eickman, PharmD, describe the goals of six sigma methodology and review examples of its application within pharmacy dispensing, reviews DMAIC methodology and describes how lean and six sigma can be used to achieve the same goals of patient safety. 

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Let’s Take It One CYP At a Time: Unraveling the Role of CYP2B6 in Methadone Metabolism

Dimple R. Dhakal, PharmD describes the pharmacodynamics and pharmacokinetics of methadone, identifies and discusses clinical practice guidelines for the safe use of methadone and evaluates evidence for CYP2B6-guided methadone use.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Opioid Stewardship: A Focus on Opioids at Transitions of Care

Julie L. Cunningham, PharmD, BCPP; M. Zeeshan Rizwan, PharmD, BCPS, BCCCP; Christi A. Jen, PharmD, BCPS, FASHP, FAzPA; and Kristina L. Wescott, PharmD, BCPS identify appropriate non-stigmatizing language related to opioids and addiction in the context of patient care discussions, discuss risks for opioid harms related to individual risks at points of transitions of patient care, review interventions for high-risk opioid patients across transitions of care and identify resources in multiple areas of practice to support patient care for opioid use.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

When the Beat Drops: Pharmacotherapy in Cardiac Arrest

Hannah M. Brokmeier, PharmD, describes the pathophysiology behind the pharmacologic targets in ACLS, discusses the role of vasopressin, steroids, and epinephrine in cardiac arrest management, and explains the mechanism and evidence behind administering adjunct agents during ACLS.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

To Augmentation and Beyond: Strategies for Treatment-Resistant Depression

Lauren M. Dolly, PharmD, recalls the etiology and pathophysiology of TRD, discusses the role of pharmacogenomics in L-methylfolate for TRD, selects a preferred agent for a patient with TRD with evidence to support its use.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Oops! AI Did It Again!

Pooja Ojha, PharmD, describes what bias in artificial intelligence entails, discusses implications of bias in artificial intelligence, evaluates mitigation strategies for bias in artificial intelligence.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.