Mayo Clinic Pharmacy Grand Rounds

The Importance of De-Livering Micronutrients in Cirrhotic Patients

Danielle M. Hess, PharmD (@dhess_09) describes the role of nutrition in cirrhosis and deficiency patterns as it relates to disease severity, evaluates literature depicting the impact of vitamin A, vitamin D, and zinc deficiencies on complications associated with cirrhosis and discusses micronutrient supplementation and monitoring recommendations for the management of cirrhosis. 

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Time to Make A-MENDS? Propofol vs. Dexmedetomidine for Light Sedation

Hannah M. Brokmeier, PharmD (@hannahbrokmeier) reviews current accepted standards in sedation practices, compares pharmacologic properties of propofol and dexmedetomidine for light sedation and evaluates evidence for choice of optimal sedative agent in light sedation.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Picking the P2Y12: Antiplatelet Choices Following Percutaneous Coronary Intervention

Cassandra J. Schmitt, PharmD (@cjschmitt2) identifies guideline recommendations for antiplatelet agents following percutaneous coronary intervention (PCI), reviews the literature examining the safety and efficacy of clopidogrel, ticagrelor, and prasugrel and discusses factors that influence the selection of a P2Y12 agent following PCI. 

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Got Drug? An Organizational Guide to Drug Shortage Management

Mary A. Gilmer, PharmD, MHA, BCPS reviews common causes and origins of drug shortages, describes the impacts and implications of drug shortages and discusses strategies and processes for drug shortage management.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Pop Pop. Fizz Fizz. Oh What a Relief It Is. New CPIC Proton Pump Inhibitor Guidelines

Ashley Kate Ragan, PharmD defines actionable proton pump inhibitor (PPI) drug-gene associations, discusses current pharmacogenomic PPI guidelines, including the 2018 Dutch Pharmacogenomic Working Group (DPWG) and 2020 Clinical Pharmacogenetic Implementation Consortium (CPIC) and reviews primary literature depicting CYP2C19 guided PPI dosing.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

You Take My Breath Away: Controversies in RSI

Alicia E. Mattson, PharmD, BCPS, BCCCP (@AM_EM_PharmD) describes the goals of pharmacotherapy in RSI, discusses literature surrounding medication choice and dose for RSI and selects an appropriate induction and paralytic medication for a patient requiring RSI. 

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

At the Heart of Sex: Cardiovascular Implications of Gender-Affirming Hormone Therapy

Nathan T. Smith, PharmD, BCPS recalls the clinical presentation of gender incongruence, identifies current treatment options for transgender men and women and describes potential cardiovascular risks associated with gender-affirming hormone therapy.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Marking the Way: The Future of Vasopressors

Mikaela Hofer, Pharm.D., BSPS, BCCCP (@mikaelamhofer) identifies limitations of current vasopressor agents for the treatment of septic shock, reviews novel vasopressor therapies with a current or potential role in the management of septic shock and describes advancements in the development of biomarkers and pharmacogenomics for the monitoring and individualization of vasopressor treatment. 

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Targeting the Un-targetable: Initial Treatment of Acute Myeloid Leukemia without Targetable Mutations

Allison Golbach, PharmD, BCPS (@AllisonGPharmD) describes epidemiology, pathophysiology, and prognosis of acute myeloid leukemia (AML), reviews literature supporting induction regimens for patients with AML without targetable mutations and discusses how to select between AML induction regimens based on patient-specific factors.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

It's MAGic: Roles of Intravenous Magnesium in Emergency Medicine

Nicole Hlavacek, PharmD (@HlavacekPharmD) recognizes the proposed mechanism of magnesium in different pathologies, recalls dosing and administration rates for magnesium and describes effectiveness of magnesium.

For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter!

You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.